当院について｜西宮市甲子園口の小児科・小児脳神経内科「永瀬医院」

院長ご挨拶

永瀬医院は、祖父の代から地域で親しまれてきた小さな医院です。
その思いを受け継ぐ三代目として、
お子さんとご家族に寄り添う場所を目指して、新たに開院しました。

これまで神戸大学や兵庫県立こども病院で、
熱性けいれん、てんかん、発達や行動の相談など、
さまざまな子どもたちの診療に携わってきました。
そのなかで、「ちょっと気になる」「誰かに相談してみたい」という気持ちを安心して話せる場所があることの大切さを感じてきました。

軽い発達の気がかりや、学校・家庭でのちょっとした困りごとでも、
その背景に体や神経の問題が隠れていないかも含め、
一緒にこれからの関わり方を考えていきます。
もちろん、風邪や発熱、アレルギー、予防接種、健診など、
日々の健康管理も幅広く対応しています。

医療だけでなく、保健・福祉・教育の方々と力を合わせながら、この地域で「誰ひとり取り残さない」子育て支援の形をつくっていきたいと考えています。

小さな頃から大きくなるまで、
ご家族のそばで成長を見守る医院でありたい。
それが私たちの願いです。

永瀬医院小児科・小児脳神経内科
院長　永瀬裕朗

院長経歴

学歴

1984年　西宮市立上甲子園小学校　卒業
1990年　甲陽学院高等学校　卒業
1997年　神戸大学医学部　卒業
2003年　神戸大学大学院医学系研究科　修了

勤務歴

1997年　神戸大学医学部附属病院小児科　研修医
1998年　市立川西病院小児科　研修医
2003年　ジョンズ・ホプキンス大学医学部生化学教室ポスドクフェロー
2005年　兵庫県立こども病院脳神経内科　医長
2015年　神戸大学医学部附属病院親と子の心療部　講師
2018年　神戸大学大学院医学研究科内科系講座小児科学　准教授
2019年　神戸大学大学院医学研究科内科系講座小児科学分野
　　　　こども急性疾患学部門小児統合健康学領域　特命教授
2023年　神戸大学医学部附属病院親と子の心療部　部長（兼務）
2024年　神戸大学大学院医学研究科内科系講座小児科学分野
　　　　小児神経学・発達行動小児科学部門　特命教授
2024年　神戸大学医学部附属病院てんかんセンター　副センター長（兼務）
2025年　永瀬医院開院、神戸大学客員教授

資格

医学博士
日本小児科学会　小児科専門医・指導医
日本小児神経学会　小児神経専門医
日本てんかん学会　てんかん専門医・指導医
日本小児精神神経学会　認定医
子どものこころ専門医機構　子どものこころ専門医

役職

日本小児科学会代議員　
日本小児神経学会評議員
日本小児精神神経学会代議員
日本子ども虐待医学会代議員

など

業績一覧

講演

第67回日本小児神経学会学術集会　2025年6月4日〜7日, 教育講演　急性脳症のエビデンスに基づいた治療永瀬裕朗
17^th Asian Oceanian Congress of Child Neurology, 2025年9月16−20日, New Delhi, India　Developing Evidence-Based Management for Infection-Triggered Acute Encephalopathy(ITES): Febrile Seizure–ITES Spectrum Hypothesis and Insights from the FACE Registry, Hiroaki Nagase
Annual State Conference PUNPEDICON 2025, 2025年11月15−16日, Bathinda, India. Febrile Seizure–Infection-Triggered Acute Encephalopathy(ITES) Hypothesis and Insights from the FACE Registry, Hiroaki Nagase
永瀬裕朗　医療・療育の立場から．シンポジウムこどもの育ちのインクルーシブな支援をめざして－神戸市の試み－　日本保育学会　第77回大会　2024年5月11日―12日　神戸（オンライン）
永瀬裕朗．脳保護を指向した小児神経集中治療、　シンポジウム「脳保護のための小児神経集中治療」. 第66回日本小児神経学会学術集会、2024年5月30日-6月1日、名古屋
永瀬　裕朗．神経救急集中治療体制の整備は、急性脳症への進展と神経学的後遺症を減らしうる．シンポジウム小児の急性脳症の診療最前線．第 28回日本神経感染症学会総会・学術大会、2024年 10月 11日～12 日、東京
永瀬　裕朗．児童相談所における医療・保健領域に医療機関の小児科医として期待すること　シンポジウム　児童相談所における医療・保健領域の役割と課題．日本子ども虐待防止学会第30回学術集会かがわ大会 2024年11月30日〜12月１日、高松
永瀬　裕朗，シンポジウム　小児急性脳症 up-to-date，急性脳症FACEレジストリ、第64回日本小児神経学会総会　2022年6月2日– 5日　高崎
永瀬　裕朗，非けいれん性てんかん重積状態（NCSE）の考え方学会委員会主催セミナー(1) 小児てんかん重積状態・けいれん重積状態治療ガイドライン改訂ワーキンググループ，小児けいれん重積治療ガイドライン2017の改訂の要点、第64回日本小児神経学会総会　2022年6月2日– 5日　高崎
永瀬裕朗, 急性脳症のABCー診断から治療までー第63回日本小児神経学会 2021年5月26日　福岡

著書・論文

Heidi M. Feldman et al.eds, 総監訳　永瀬裕朗．発達行動小児科学. 東京, エルゼビア・ジャパン, 2025.
永瀬裕朗　ナースのための小児科学　p60-67 中外医学社　2024
永瀬裕朗　小児の急性脳症　今日の診断指針　第９版　p1800-1802医学書院　2025
永瀬裕朗　生理機能の特徴保育者のための　わかりやすい子どもの保健　第２版　p32-38 総合医学社　2024
永瀬裕朗、CQ7 非けいれん性てんかん重積状態を治療すると、しない場合に比べて転帰は改善するか、CQ9難治性てんかん重積状態に対して昏睡療法は有用か、CQ10 超難治性てんかん重積状態に対する介入は何があるか、CQ11 難治性てんかん重積状態に脳低温療法は有効か、小児てんかん重積・けいれん重積治療ガイドライン2023、監修　日本小児神経学会、編集　小児てんかん重積状態・けいれん重積状態治療ガイドライン改訂ワークンググループ、診断と治療社、80-94、 98-118、 2023.
永瀬裕朗、第4章3 急性脳症全般に対する体温管理療法（脳低温療法：目標体温32〜35℃、脳平温療法：目標体温36℃）小児急性脳症診療ガイドライン2023、監修　日本小児神経学会、編集　小児急性脳症診療ガイドライン改訂ワークンググループ、診断と治療社、51-5、 2023.
Kyono Y, Nishiyama M, Yamaguchi H, Kawamura A, Oikawa S, Tokumoto S, Imai T, Murakami S, Nozu K, Mishina H, Nagase H. Impact of the COVID-19 pandemic on infant neurodevelopmental outcomes. BMJ Paediatr Open. 2026 Feb 3;10(1):e003832. doi: 10.1136/bmjpo-2025-003832. PMID: 41633761; PMCID: PMC12878251.
Asagai Y, Yamaguchi H, Yamamura T, Kusuki M, Ohnuma K, Horinouchi T, Bo R, Yamamoto N, Yano Y, Nagase H, Nozu K. Epidemiological characterization and clinical utility of the multiplex PCR FilmArray™ Gastrointestinal Panel at a tertiary university hospital in Japan, 2024. Pediatr Neonatol. 2025 Dec 31:S1875-9572(25)00244-X. doi: 10.1016/j.pedneo.2025.11.009. Epub ahead of print. PMID: 41521089.
Nomura Y, Nomura J, Tamada K, Eguchi N, Torigata K, Tokumoto S, Nemoto A, Shirafuji T, Yamamoto K, Hishimoto A, Nagase H, Nishikawa T, Takumi T. Isogenic modeling of 1q21.1 reciprocal CNVs in human ES cells reveals divergent neurodevelopmental trajectories. Hum Mol Genet. 2026 Feb 9;35(2):ddaf184. doi: 10.1093/hmg/ddaf184. PMID: 41370233.
Kimura M, Togo M, Matoba K, Otani M, Sekiguchi K, Fujimoto Y, Chiba K, Nagase H, Matsumoto R. Relationship between cortical tuber subtypes and interictal epileptiform discharges in tuberous sclerosis complex: MRI and scalp-EEG study. Seizure. 2025 Dec;133:149-156. doi: 10.1016/j.seizure.2025.10.014. Epub 2025 Oct 21. PMID: 41138587.
Omata T, Sakuma H, Nagase H, Abe Y, Kuki I, Okumura A, Maegaki Y, Murayama K, Sakai Y, Hoshino A, Mizuguchi M, Takanashi JI. National study on pediatric acute encephalopathy in Japan (April 2020 to October 2023): Insights from the third study. Brain Dev. 2025 Aug;47(4):104387. doi: 10.1016/j.braindev.2025.104387. Epub 2025 Jun 25. PMID: 40570505.
Yamaguchi H, Maruyama A, Nishiyama M, Ueda T, Hongo H, Oikawa S, Tokumoto S, Tomioka K, Matsui S, Hayashi T, Tanaka R, Nozu K, Nagase H. Description of Patterns in Reduced-Lead Electroencephalography Performed for Suspected Electrographic Seizures in Pediatric Patients With Altered Mental Status Using Standardized Terminology. Pediatr Neurol. 2025 Aug;169:21-30. doi: 10.1016/j.pediatrneurol.2025.05.011. Epub 2025 May 13. PMID: 40449416.
Hanafusa H, Yamaguchi H, Morisada N, Ye MJ, Oikawa S, Tokumoto S, Nishiyama M, Nozu K, Nagase H. Identification of Genetic Variants in Status Epilepticus Associated With Fever. Brain Behav. 2025 Feb;15(2):e70279. doi: 10.1002/brb3.70279. PMID: 39915231; PMCID: PMC11802276.
Tokumoto S, Nishiyama M, Yamaguchi H, Sano K, Motobayashi M, Kashiwagi M, Hattori Y, Maruyama A, Toyoshima D, Nakagawa T, Kawano G, Nagase H. Epidemiology and treatment trends for acute encephalopathy under the impact of SARS-CoV-2 pandemic based on a prospective multicenter consecutive case registry. J Neurol Sci. 2025 Feb 15;469:123377. doi: 10.1016/j.jns.2024.123377. Epub 2025 Jan 3. PMID: 39778301.
Kikuchi K, Kuki I, Nishiyama M, Ueda Y, Matsuura R, Shiohama T, Nagase H, Akiyama T, Sugai K, Hayashi K, Murakami K, Yamamoto H, Fukuda T, Kashiwagi M, Maegaki Y. Japanese guidelines for treatment of pediatric status epilepticus – 2023. Brain Dev. 2025 Feb;47(1):104306. doi: 10.1016/j.braindev.2024.104306. Epub 2024 Dec 2. PMID: 39626562.
Ueda T, Nishiyama M, Yamaguchi H, Soma K, Ishida Y, Maruyama A, Nozu K, Nagase H. Efficacy and safety of buccal midazolam for seizures outside the hospital: Real-world clinical experience. Brain Dev. 2024 Nov;46(10):332-338. doi: 10.1016/j.braindev.2024.09.005. Epub 2024 Sep 23. PMID: 39317519.
Oikawa S, Yamaguchi H, Nishiyama M, Ito T, Kawamura A, Sameshima T, Soma K, Ueda T, Tokumoto S, Ishida Y, Kurosawa H, Nozu K, Maruyama A, Tanaka R, Nagase H. Elevated cerebrospinal fluid neuronal injury biomarkers within 24 hours of onset in infection-triggered acute encephalopathy compared to complex febrile seizures. J Neurol Sci. 2024 Nov 15;466:123238. doi: 10.1016/j.jns.2024.123238. Epub 2024 Sep 12. PMID: 39278173.
Hanafusa H, Yamaguchi H, Morisada N, Ye MJ, Matsumoto R, Nagase H, Nozu K. End-stage ADPKD with a low-frequency PKD1 mosaic variant accelerated by chemoradiotherapy. Hum Genome Var. 2024 Mar 28;11(1):17. doi: 10.1038/s41439-024-00273-0. PMID: 38548773; PMCID: PMC10978896.
Kyono Y, Nishiyama M, Kawamura A, Oikawa S, Tokumoto S, Yamaguchi H, Tomioka K, Nozu K, Mishina H, Nagase H. Association of perinatal factors with neurodevelopmental referrals in a population-based cohort study in Japan. Sci Rep. 2024 Feb 12;14(1):3492. doi: 10.1038/s41598-024-54167-w. PMID: 38347064; PMCID: PMC10861581.
Kasai M, Sakuma H, Abe Y, Kuki I, Maegaki Y, Murayama K, Murofushi Y, Nagase H, Nishiyama M, Okumura A, Sakai Y, Tada H, Mizuguchi M, Takanashi JI; Japanese Pediatric Neuro-COVID-19 Study Group. Clinical characteristics of SARS-CoV-2-associated encephalopathy in children: Nationwide epidemiological study. J Neurol Sci. 2024 Feb 15;457:122867. doi: 10.1016/j.jns.2024.122867. Epub 2024 Jan 3. PMID: 38199023.
Sameshima T, Ashina M, Fukuda T, Kido T, Abe S, Watanabe Y, Sato I, Yano Y, Tanimura K, Nagase H, Nozu K, Fujioka K. Range of protein induced by vitamin K absence or antagonist-II levels in neonates at birth. Sci Rep. 2024 Jan 9;14(1):921. doi: 10.1038/s41598-024-51674-8. PMID: 38195988; PMCID: PMC10776853.
Nishiyama M, Kyono Y, Yamaguchi H, Kawamura A, Oikawa S, Tokumoto S, Tomioka K, Nozu K, Nagase H. Association of early bedtime at 3 years of age with higher academic performance and better non-cognitive skills in elementary school. Sci Rep. 2023 Nov 27;13(1):20926. doi: 10.1038/s41598-023-48280-5. PMID: 38017093; PMCID: PMC10684487.
Hongo H, Nishiyama M, Ueda T, Ishida Y, Kasai M, Tanaka R, Nagase H, Maruyama A. Comparison of neurological manifestation in children with and without coronavirus 2019 experiencing seizures with fever. Epilepsy Behav Rep. 2023 Oct 5;24:100625. doi: 10.1016/j.ebr.2023.100625. PMID: 37860712; PMCID: PMC10583046.
Nagase H, Yamaguchi H, Tokumoto S, Ishida Y, Tomioka K, Nishiyama M, Nozu K, Maruyama A. Timing of therapeutic interventions against infection-triggered encephalopathy syndrome: a scoping review of the pediatric literature. Front Neurosci. 2023 Aug 22;17:1150868. doi: 10.3389/fnins.2023.1150868. PMID: 37674514; PMCID: PMC10477367.
Sakuma H, Takanashi JI, Muramatsu K, Kondo H, Shiihara T, Suzuki M, Okanari K, Kasai M, Mitani O, Nakazawa T, Omata T, Shimoda K, Abe Y, Maegaki Y, Murayama K, Murofushi Y, Nagase H, Okumura A, Sakai Y, Tada H, Mizuguchi M; Japanese Pediatric Neuro-COVID-19 Study Group. Severe pediatric acute encephalopathy syndromes related to SARS-CoV-2. Front Neurosci. 2023 Feb 27;17:1085082. doi: 10.3389/fnins.2023.1085082. PMID: 36922927; PMCID: PMC10008884.
Hanafusa H, Yamaguchi H, Kondo H, Nagasaka M, Juan Ye M, Oikawa S, Tokumoto S, Tomioka K, Nishiyama M, Morisada N, Matsuo M, Nozu K, Nagase H. Dravet syndrome and hemorrhagic shock and encephalopathy syndrome associated with an intronic deletion of SCN1A. Brain Dev. 2023 Jun;45(6):317-323. doi: 10.1016/j.braindev.2023.01.008. Epub 2023 Feb 9. PMID: 36774261.
Tanaka T, Yamaguchi H, Ishida Y, Tomioka K, Nishiyama M, Toyoshima D, Maruyama A, Takeda H, Kurosawa H, Tanaka R, Nozu K, Nagase H. Clinical and laboratory characteristics of complex febrile seizures in the acute phase: a case-series study in Japan. BMC Neurol. 2023 Jan 18;23(1):28. doi: 10.1186/s12883-023-03051-7. PMID: 36653748; PMCID: PMC9847116.
Tomioka K, Nishiyama M, Tokumoto S, Yamaguchi H, Aoki K, Seino Y, Toyoshima D, Kurosawa H, Tada H, Sakuma H, Nozu K, Maruyama A, Tanaka R, Iijima K, Nagase H. Time course of serum cytokine level changes within 72 h after onset in children with acute encephalopathy and febrile seizures. BMC Neurol. 2023 Jan 7;23(1):7. doi: 10.1186/s12883-022-03048-8. PMID: 36609211; PMCID: PMC9824967.
Yamaguchi H, Nozu K, Hanafusa H, Nambu Y, Kido T, Kondo A, Tamura A, Awano H, Morioka I, Nagase H, Ishida A. Impact after the Change from Voluntary to Universal Oral Rotavirus Vaccination on Consecutive Emergency Department Visits for Acute Gastroenteritis among Children in Kobe City, Japan (2016-2022). Vaccines (Basel). 2022 Oct 29;10(11):1831. doi: 10.3390/vaccines10111831. PMID: 36366340; PMCID: PMC9693232.
Tomioka K, Nishiyama M, Tokumoto S, Yamaguchi H, Nozu K, Nagase H. Behavioral Therapy for Children with Avoidant/Restrictive Food Intake Disorder Dependent on Tube or Oral Enteral Nutrient Formula: A Feasibility Study. Kobe J Med Sci. 2022 Mar 24;67(4):E155-E160. PMID: 35368003; PMCID: PMC9677579.
Kurosawa H, Shiima Y, Miyakoshi C, Nezu M, Someya M, Yoshida M, Nagase H, Nozu K, Kosaka Y, Iijima K. The association between prehospital vital signs of children and their critical clinical outcomes at hospitals. Sci Rep. 2022 Mar 25;12(1):5199. doi: 10.1038/s41598-022-09271-0. PMID: 35338242; PMCID: PMC8956615.
Tokumoto S, Nishiyama M, Yamaguchi H, Tomioka K, Ishida Y, Toyoshima D, Kurosawa H, Nozu K, Maruyama A, Tanaka R, Iijima K, Nagase H. Prognostic effects of treatment protocols for febrile convulsive status epilepticus in children. BMC Neurol. 2022 Mar 5;22(1):77. doi: 10.1186/s12883-022-02608-2. PMID: 35247987; PMCID: PMC8897930.
Yamaguchi H, Nozu K, Ishiko S, Kondo A, Yamamoto N, Tamura A, Aoto Y, Unzaki A, Ishibashi K, Morioka I, Nagase H, Ishida A. Multivariate analysis of the impact of weather and air pollution on emergency department visits for unprovoked seizure among children: A retrospective clinical observational study. Epilepsy Behav. 2021 Dec;125:108434. doi: 10.1016/j.yebeh.2021.108434. Epub 2021 Nov 24. PMID: 34837841.
Yamaguchi H, Nozu K, Ishiko S, Kondo A, Ninchoji T, Nagano C, Takeda H, Unzaki A, Ishibashi K, Morioka I, Nagase H, Iijima K, Ishida A. Impact of the State of Emergency during the COVID-19 Pandemic in 2020 on Asthma Exacerbations among Children in Kobe City, Japan. Int J Environ Res Public Health. 2021 Oct 29;18(21):11407. doi: 10.3390/ijerph182111407. PMID: 34769923; PMCID: PMC8583023.
Yamaguchi H, Nishiyama M, Tomioka K, Hongo H, Tokumoto S, Ishida Y, Toyoshima D, Kurosawa H, Nozu K, Maruyama A, Tanaka R, Nagase H. Growth and differentiation factor-15 as a potential prognostic biomarker for status-epilepticus-associated-with-fever: A pilot study. Brain Dev. 2022 Mar;44(3):210-220. doi: 10.1016/j.braindev.2021.10.003. Epub 2021 Oct 27. PMID: 34716034.
Yamaguchi H, Nozu K, Ishiko S, Nagase H, Ninchoji T, Nagano C, Takeda H, Unzaki A, Ishibashi K, Morioka I, Iijima K, Ishida A. Epidemiological impact of universal varicella vaccination on consecutive emergency department visits for varicella and its economic impact among children in Kobe City, Japan. J Infect Chemother. 2022 Jan;28(1):35-40. doi: 10.1016/j.jiac.2021.09.017. Epub 2021 Oct 5. PMID: 34620534.
Ninchoji T, Nozu K, Kondo A, Ishiko S, Unzaki A, Nagano C, Yamaguchi H, Takeda H, Hayashi T, Tanaka R, Nagase H, Iijima K, Ishida A. Current management for foreign body and toxic agent ingestion in a pediatric primary emergency center. Minerva Pediatr (Torino). 2024 Dec;76(6):751-757. doi: 10.23736/S2724-5276.21.06334-5. Epub 2021 Sep 13. PMID: 34515442.
Ishida Y, Nishiyama M, Yamaguchi H, Tomioka K, Takeda H, Tokumoto S, Toyoshima D, Maruyama A, Seino Y, Aoki K, Nozu K, Kurosawa H, Tanaka R, Iijima K, Nagase H. Early steroid pulse therapy for children with suspected acute encephalopathy: An observational study. Medicine (Baltimore). 2021 Jul 30;100(30):e26660. doi: 10.1097/MD.0000000000026660. PMID: 34397692; PMCID: PMC8322503.
Yamaguchi H, Nozu K, Ishiko S, Nagase H, Ninchoji T, Nagano C, Takeda H, Unzaki A, Ishibashi K, Morioka I, Iijima K, Ishida A. Multivariate analysis of the impact of weather and air pollution on emergency department visits for night-time headaches among children: retrospective, clinical observational study. BMJ Open. 2021 Apr 12;11(4):e046520. doi: 10.1136/bmjopen-2020-046520. PMID: 33846155; PMCID: PMC8047993.
Horinouchi T, Maeyama K, Nagai M, Mizobuchi M, Takagi Y, Okada Y, Kato T, Nishimura M, Kawasaki Y, Yoshioka M, Takada S, Matsumoto H, Nakamachi Y, Saegusa J, Fukushima S, Fujioka K, Tomioka K, Nagase H, Nozu K, Iijima K, Nishimura N. Genetic Analysis of UGT1A1 Polymorphisms Using Preserved Dried Umbilical Cord for Assessing the Potential of Neonatal Jaundice as a Risk Factor for Autism Spectrum Disorder in Children. J Autism Dev Disord. 2022 Feb;52(2):483-489. doi: 10.1007/s10803-021-04941-w. Epub 2021 Mar 17. PMID: 33730321.
Nishiyama M, Ishida Y, Yamaguchi H, Tokumoto S, Tomioka K, Hongo H, Toyoshima D, Maruyama A, Kurosawa H, Tanaka R, Nozu K, Iijima K, Nagase H. Prediction of AESD and neurological sequelae in febrile status epilepticus. Brain Dev. 2021 May;43(5):616-625. doi: 10.1016/j.braindev.2021.01.004. Epub 2021 Feb 7. PMID: 33563484.
Maruyama A, Tokumoto S, Yamaguchi H, Ishida Y, Tanaka T, Tomioka K, Nishiyama M, Fujita K, Toyoshima D, Nagase H. Early non-convulsive seizures are associated with the development of acute encephalopathy with biphasic seizures and late reduced diffusion. Brain Dev. 2021 Apr;43(4):548-555. doi: 10.1016/j.braindev.2020.11.012. Epub 2020 Dec 17. PMID: 33342582.
Yamaguchi H, Nagase H, Tokumoto S, Tomioka K, Nishiyama M, Takeda H, Ninchoji T, Nagano C, Iijima K, Nozu K. Prevalence of Wilson disease based on genome databases in Japan. Pediatr Int. 2021 Aug;63(8):918-922. doi: 10.1111/ped.14565. Epub 2021 Jul 16. PMID: 33260258.
Yamaguchi H, Nishiyama M, Tokumoto S, Ishida Y, Tomioka K, Aoki K, Seino Y, Toyoshima D, Takeda H, Kurosawa H, Sakuma H, Tada H, Nozu K, Maruyama A, Tanaka R, Iijima K, Nagase H. Elevated cytokine, chemokine, and growth and differentiation factor-15 levels in hemorrhagic shock and encephalopathy syndrome: A retrospective observational study. Cytokine. 2021 Jan;137:155324. doi: 10.1016/j.cyto.2020.155324. Epub 2020 Oct 5. PMID: 33032108.
Nishiyama M, Yamaguchi H, Ishida Y, Tomioka K, Takeda H, Nishimura N, Nozu K, Mishina H, Iijima K, Nagase H. Seizure prevalence in children aged up to 3 years: a longitudinal population-based cohort study in Japan. BMJ Open. 2020 Sep 10;10(9):e035977. doi: 10.1136/bmjopen-2019-035977. PMID: 32912975; PMCID: PMC7485243.
Ishida Y, Nishiyama M, Yamaguchi H, Tomioka K, Tanaka T, Takeda H, Tokumoto S, Toyoshima D, Maruyama A, Seino Y, Aoki K, Nozu K, Nishimura N, Kurosawa H, Iijima K, Nagase H. Thiamylal anaesthetic therapy for febrile refractory status epilepticus in children. Seizure. 2020 Aug;80:12-17. doi: 10.1016/j.seizure.2020.03.012. Epub 2020 May 14. PMID: 32480278.
Kasai M, Shibata A, Hoshino A, Maegaki Y, Yamanouchi H, Takanashi JI, Yamagata T, Sakuma H, Okumura A, Nagase H, Ishii A, Goto T, Oka A, Mizuguchi M. Epidemiological changes of acute encephalopathy in Japan based on national surveillance for 2014-2017. Brain Dev. 2020 Aug;42(7):508-514. doi: 10.1016/j.braindev.2020.04.006. Epub 2020 Apr 22. PMID: 32360071.
Yamaguchi H, Nishiyama M, Tokumoto S, Ishida Y, Tomioka K, Aoki K, Seino Y, Toyoshima D, Takeda H, Kurosawa H, Nozu K, Maruyama A, Tanaka R, Iijima K, Nagase H. Detailed characteristics of acute encephalopathy with biphasic seizures and late reduced diffusion: 18-year data of a single-center consecutive cohort. J Neurol Sci. 2020 Apr 15;411:116684. doi: 10.1016/j.jns.2020.116684. Epub 2020 Jan 16. PMID: 32001378.
Yamaguchi H, Taniguchi-Ikeda M, Nagase H, Ito Y, Tokumoto S, Toyoshima D, Enkhjargal S, Nishiyama M, Awano H, Kurosawa H, Kasai M, Maruyama A, Iijima K. Acute rhabdomyolysis following viral infection with coxsackie A4 in a 50-day-old infant with Fukuyama congenital muscular dystrophy. J Infect Chemother. 2020 May;26(5):516-519. doi: 10.1016/j.jiac.2019.12.015. Epub 2020 Jan 23. PMID: 31983616.
Katsuyama A, Kusuhara S, Awano H, Nagase H, Matsumiya W, Nakamura M. A case of probable Vogt-Koyanagi-Harada disease in a 3-year-old girl. BMC Ophthalmol. 2019 Aug 13;19(1):179. doi: 10.1186/s12886-019-1192-0. PMID: 31409322; PMCID: PMC6693137.
Tomioka K, Nishiyama M, Nagase H, Ishida Y, Tanaka T, Tokumoto S, Yamaguchi H, Toyoshima D, Maruyama A, Fujita K, Aoki K, Seino Y, Nozu K, Nishimura N, Kurosawa H, Iijima K. Detailed clinical course of fatal acute encephalopathy in children. Brain Dev. 2019 Sep;41(8):691-698. doi: 10.1016/j.braindev.2019.04.012. Epub 2019 Jul 20. Erratum in: Brain Dev. 2022 Nov;44(10):771-772. doi: 10.1016/j.braindev.2022.07.006. PMID: 31337523.
Awano H, Nagai M, Bo R, Murao M, Ishida Y, Tanaka T, Tomioka K, Nishiyama M, Nagase H, Iijima K. Preliminary Effectiveness and Safety of High Frequency Oscillation in Addition to Mechanical Insufflation and Exsufflation for Intratracheal Mucus Removal in Patients With Neuromuscular Disease: Protocol for a Prospective Study. JMIR Res Protoc. 2019 Jun 27;8(6):e12102. doi: 10.2196/12102. PMID: 31250831; PMCID: PMC6620888.
Yamaguchi H, Nagase H, Nishiyama M, Tokumoto S, Toyoshima D, Akasaka Y, Maruyama A, Iijima K. Fibrocartilaginous Embolism of the Spinal Cord in Children: A Case Report and Review of Literature. Pediatr Neurol. 2019 Oct;99:3-6. doi: 10.1016/j.pediatrneurol.2019.04.013. Epub 2019 Apr 26. PMID: 31201068.
Tanaka T, Nagase H, Yamaguchi H, Ishida Y, Tomioka K, Nishiyama M, Toyoshima D, Maruyama A, Fujita K, Nozu K, Nishimura N, Kurosawa H, Tanaka R, Iijima K. Predicting the outcomes of targeted temperature management for children with seizures and/or impaired consciousness accompanied by fever without known etiology. Brain Dev. 2019 Aug;41(7):604-613. doi: 10.1016/j.braindev.2019.03.007. Epub 2019 Mar 28. PMID: 30929765.
Nishiyama M, Nagase H, Tomioka K, Tanaka T, Yamaguchi H, Ishida Y, Toyoshima D, Fujita K, Maruyama A, Sasaki K, Oyazato Y, Nakagawa T, Takami Y, Nozu K, Nishimura N, Nakashima I, Iijima K. Clinical time course of pediatric acute disseminated encephalomyelitis. Brain Dev. 2019 Jun;41(6):531-537. doi: 10.1016/j.braindev.2019.02.011. Epub 2019 Mar 2. PMID: 30833092.
Iwatani S, Yoshida M, Yamana K, Kurokawa D, Kuroda J, Thwin KKM, Uemura S, Takafuji S, Nino N, Koda T, Mizobuchi M, Nishiyama M, Fujioka K, Nagase H, Morioka I, Iijima K, Nishimura N. Isolation and Characterization of Human Umbilical Cord-derived Mesenchymal Stem Cells from Preterm and Term Infants. J Vis Exp. 2019 Jan 26;(143). doi: 10.3791/58806. PMID: 30741254.
Yamaguchi H, Nagase H, Nishiyama M, Tokumoto S, Ishida Y, Tomioka K, Tanaka T, Fujita K, Toyoshima D, Nishimura N, Kurosawa H, Nozu K, Maruyama A, Tanaka R, Iijima K. Nonconvulsive Seizure Detection by Reduced-Lead Electroencephalography in Children with Altered Mental Status in the Emergency Department. J Pediatr. 2019 Apr;207:213-219.e3. doi: 10.1016/j.jpeds.2018.11.019. Epub 2018 Dec 7. PMID: 30528574.
Nishiyama M, Takami Y, Ishida Y, Tomioka K, Tanaka T, Nagase H, Nakagawa T, Tokumoto S, Yamaguchi H, Toyoshima D, Maruyama A, Nozu K, Nishimura N, Iijima K. Lipid and thyroid hormone levels in children with epilepsy treated with levetiracetam or carbamazepine: A prospective observational study. Epilepsy Behav. 2019 Jan;90:15-19. doi: 10.1016/j.yebeh.2018.11.003. Epub 2018 Nov 27. PMID: 30500483.
Yamaguchi H, Nagase H, Yoshida S, Tokumoto S, Hayashi K, Toyoshima D, Kurosawa H, Tanaka T, Maruyama A, Iijima K. Acute encephalopathy with biphasic seizures and late reduced diffusion accompanied by Takotsubo cardiomyopathy. Brain Dev. 2019 Mar;41(3):305-309. doi: 10.1016/j.braindev.2018.10.002. Epub 2018 Oct 13. PMID: 30327157.
Nishiyama M, Nagase H, Tomioka K, Tanaka T, Yamaguchi H, Ishida Y, Toyoshima D, Fujita K, Maruyama A, Kurosawa H, Uetani Y, Nozu K, Taniguchi-Ikeda M, Morioka I, Takada S, Iijima K. Fosphenytoin vs. continuous midazolam for pediatric febrile status epilepticus. Brain Dev. 2018 Nov;40(10):884-890. doi: 10.1016/j.braindev.2018.08.001. Epub 2018 Aug 23. PMID: 30144969.
Belal H, Nakashima M, Matsumoto H, Yokochi K, Taniguchi-Ikeda M, Aoto K, Amin MB, Maruyama A, Nagase H, Mizuguchi T, Miyatake S, Miyake N, Iijima K, Nonoyama S, Matsumoto N, Saitsu H. De novo variants in RHOBTB2, an atypical Rho GTPase gene, cause epileptic encephalopathy. Hum Mutat. 2018 Aug;39(8):1070-1075. doi: 10.1002/humu.23550. Epub 2018 May 25. PMID: 29768694.
Shimojima K, Okamoto N, Ohmura K, Nagase H, Yamamoto T. Infantile spasms related to a 5q31.2-q31.3 microdeletion including PURA. Hum Genome Var. 2018 Mar 29;5:18007. doi: 10.1038/hgv.2018.7. PMID: 29619234; PMCID: PMC5874397.
Tomioka K, Nagase H, Tanaka T, Nishiyama M, Yamaguchi H, Ishida Y, Toyoshima D, Maruyama A, Fujita K, Taniguchi-Ikeda M, Nozu K, Morioka I, Nishimura N, Kurosawa H, Uetani Y, Iijima K. Early risk factors for mortality in children with seizure and/or impaired consciousness accompanied by fever without known etiology. Brain Dev. 2018 Aug;40(7):552-557. doi: 10.1016/j.braindev.2018.02.015. Epub 2018 Mar 19. PMID: 29567266.
Nishiyama M, Morioka I, Taniguchi-Ikeda M, Mori T, Tomioka K, Nakanishi K, Fujimura J, Nishimura N, Nozu K, Nagase H, Ishibashi K, Ishida A, Iijima K. Clinical features predicting group A streptococcal pharyngitis in a Japanese paediatric primary emergency medical centre. J Int Med Res. 2018 May;46(5):1791-1800. doi: 10.1177/0300060517752954. Epub 2018 Mar 8. PMID: 29517940; PMCID: PMC5991234.
Yamaguchi H, Nagase H, Ishida Y, Toyoshima D, Maruyama A, Tomioka K, Tanaka T, Nishiyama M, Fujita K, Mariko TI, Nozu K, Morioka I, Nishimura N, Kurosawa H, Takada S, Uetani Y, Iijima K. Diurnal occurrence of complex febrile seizure and their severity in pediatric patients needing hospitalization. Epilepsy Behav. 2018 Mar;80:280-284. doi: 10.1016/j.yebeh.2018.01.015. PMID: 29422395.
Maeyama K, Tomioka K, Nagase H, Yoshioka M, Takagi Y, Kato T, Mizobuchi M, Kitayama S, Takada S, Nagai M, Sakakibara N, Nishiyama M, Taniguchi-Ikeda M, Morioka I, Iijima K, Nishimura N. Congenital Cytomegalovirus Infection in Children with Autism Spectrum Disorder: Systematic Review and Meta-Analysis. J Autism Dev Disord. 2018 May;48(5):1483-1491. doi: 10.1007/s10803-017-3412-x. PMID: 29185167.
Morioka I, Kamiyoshi N, Nishiyama M, Yamamura T, Minamikawa S, Iwatani S, Nagase H, Nozu K, Nishimura N, Taniguchi-Ikeda M, Ishibashi K, Ishida A, Iijima K. Changes in the numbers of patients with acute gastroenteritis after voluntary introduction of the rotavirus vaccine in a Japanese children’s primary emergency medical center. Environ Health Prev Med. 2017 Mar 31;22(1):15. doi: 10.1186/s12199-017-0638-3. PMID: 29165124; PMCID: PMC5664845.
Sasaki K, Nagase H, Maruyama A, Fujita K, Nishiyama M, Tanaka T, Nukina S, Takumi T, Takenaka K, Oyazato Y, Nishiyama A, Kawata T, Saeki K, Takami Y, Satake-Inoue E, Iijima K, Morioka I, Uetani Y. Clinical prediction rule for neurological sequelae due to acute encephalopathy: a medical community-based validation study in Harima, Japan. BMJ Open. 2017 Nov 9;7(11):e016675. doi: 10.1136/bmjopen-2017-016675. PMID: 29127224; PMCID: PMC5695471.
Matsumoto M, Awano H, Bo R, Nagai M, Tomioka K, Nishiyama M, Ninchouji T, Nagase H, Yagi M, Morioka I, Hasegawa Y, Takeshima Y, Iijima K. Renal insufficiency mimicking glutaric acidemia type 1 on newborn screening. Pediatr Int. 2018 Jan;60(1):67-69. doi: 10.1111/ped.13438. Epub 2017 Dec 14. PMID: 29059480.
Nishiyama M, Nagase H, Matsumoto M, Tomioka K, Awano H, Tanaka T, Toyoshima D, Fujita K, Maruyama A, Oyazato Y, Saeki K, Shiraishi K, Takada S, Kaneko K, Takahashi T, Nakashima I, Iijima K. Clinical features in very early-onset demyelinating disease with anti-MOG antibody. Brain Dev. 2017 Oct;39(9):756-762. doi: 10.1016/j.braindev.2017.05.004. Epub 2017 May 24. PMID: 28551039.
Yamaguchi H, Tanaka T, Toyoshima D, Maruyama A, Ichinose A, Nagase H. Bilateral blepharoptosis in a juvenile. Brain Dev. 2017 May;39(5):452-454. doi: 10.1016/j.braindev.2016.12.006. Epub 2017 Jan 10. PMID: 28087085.
Maeyama K, Morioka I, Iwatani S, Fukushima S, Kurokawa D, Yamana K, Nishida K, Ohyama S, Fujioka K, Awano H, Taniguchi-Ikeda M, Nozu K, Nagase H, Nishimura N, Shirai C, Iijima K. Gestational age-dependency of height and body mass index trajectories during the first 3 years in Japanese small-for-gestational age children. Sci Rep. 2016 Dec 9;6:38659. doi: 10.1038/srep38659. PMID: 27934914; PMCID: PMC5146673.
Yamaguchi H, Ishida T, Yokoi T, Tanaka T, Maruyama A, Nagase H, Hasegawa D, Imadome KI, Takeda H, Kosaka Y, Uetani Y. Clinically Mild Encephalitis/Encephalopathy With a Reversible Splenial Lesion Accompanied by Epstein-Barr Virus Hemophagocytic Lymphohistiocytosis: A Case Report and Review of the Literature. J Pediatr Hematol Oncol. 2017 Mar;39(2):e92-e96. doi: 10.1097/MPH.0000000000000708. PMID: 27879539.
Matsumoto M, Awano H, Ogi M, Tomioka K, Unzaki A, Nishiyama M, Toyoshima D, Taniguchi-Ikeda M, Ishida A, Nagase H, Morioka I, Iijima K. A pediatric patient with interstitial pneumonia due to enterovirus D68. J Infect Chemother. 2016 Oct;22(10):712-5. doi: 10.1016/j.jiac.2016.03.009. Epub 2016 Apr 22. PMID: 27118532.
Yamaguchi H, Tanaka T, Maruyama A, Nagase H. Septic Encephalopathy Characterized by Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion and Early Nonconvulsive Status Epilepticus. Case Rep Neurol Med. 2016;2016:7528238. doi: 10.1155/2016/7528238. Epub 2016 Mar 9. PMID: 27051542; PMCID: PMC4804049.
Nishiyama M, Nagase H, Tanaka T, Fujita K, Kusumoto M, Kajihara S, Yamaguchi Y, Maruyama A, Takeda H, Uetani Y, Tomioka K, Toyoshima D, Taniguchi-Ikeda M, Morioka I, Takada S, Iijima K. Short and long-term outcomes in children with suspected acute encephalopathy. Brain Dev. 2016 Sep;38(8):731-7. doi: 10.1016/j.braindev.2016.02.011. Epub 2016 Mar 4. PMID: 26952815.
Kato T, Morisada N, Nagase H, Nishiyama M, Toyoshima D, Nakagawa T, Maruyama A, Fu XJ, Nozu K, Wada H, Takada S, Iijima K. Somatic mosaicism of a CDKL5 mutation identified by next-generation sequencing. Brain Dev. 2015 Oct;37(9):911-5. doi: 10.1016/j.braindev.2015.03.002. Epub 2015 Mar 27. PMID: 25819767.
Nishiyama M, Nagase H, Tanaka T, Fujita K, Maruyama A, Toyoshima D, Nakagawa T, Taniguchi-Ikeda M, Morioka I, Morisada N, Takada S, Iijima K. Demographics and outcomes of patients with pediatric febrile convulsive status epilepticus. Pediatr Neurol. 2015 May;52(5):499-503. doi: 10.1016/j.pediatrneurol.2015.02.001. Epub 2015 Feb 11. PMID: 25769239.
Fujita K, Nagase H, Nakagawa T, Saji Y, Maruyama A, Uetani Y. Non-convulsive seizures in children with infection-related altered mental status. Pediatr Int. 2015 Aug;57(4):659-64. doi: 10.1111/ped.12566. Epub 2015 Mar 25. PMID: 25523443.
Nagase H, Nishiyama M, Nakagawa T, Fujita K, Saji Y, Maruyama A. Midazolam fails to prevent neurological damage in children with convulsive refractory febrile status epilepticus. Pediatr Neurol. 2014 Jul;51(1):78-84. doi: 10.1016/j.pediatrneurol.2014.02.021. Epub 2014 Mar 4. PMID: 24830769.
Nishiyama M, Fujita K, Maruyama A, Nagase H. Two cases of traumatic head injury mimicking acute encephalopathy with biphasic seizures and late reduced diffusion. Brain Dev. 2014 Nov;36(10):928-31. doi: 10.1016/j.braindev.2013.12.006. Epub 2014 Jan 7. PMID: 24411946.
Nagase H, Nakagawa T, Aoki K, Fujita K, Saji Y, Maruyama A, Uetani Y. Therapeutic indicators of acute encephalopathy in patients with complex febrile seizures. Pediatr Int. 2013 Jun;55(3):310-4. doi: 10.1111/ped.12046. PMID: 23279186.
Mure T, Nakagawa T, Okizuka Y, Takami Y, Oyazato Y, Nagase H, Maruyama A, Adachi M, Takada S, Matsuo M. Treatment of preterm infants with West syndrome: differences due to etiology. Pediatr Int. 2012 Dec;54(6):892-8. doi: 10.1111/j.1442-200X.2012.03708.x. Epub 2012 Nov 21. PMID: 22882769.
Fujiwara T, Nagase H, Okuyama M, Hoshino T, Aoki K, Nagashima T, Nakamura H. Validity of caregivers’ reports on head trauma due to falls in young children aged less than 2 years. Clin Med Insights Pediatr. 2010 Jul 7;4:11-8. doi: 10.4137/cmped.s4624. PMID: 23761991; PMCID: PMC3667039.
Nagase H, Agren J, Saito A, Liu K, Agre P, Hazama A, Yasui M. Molecular cloning and characterization of mouse aquaporin 6. Biochem Biophys Res Commun. 2007 Jan 5;352(1):12-6. doi: 10.1016/j.bbrc.2006.10.110. Epub 2006 Oct 30. PMID: 17112474; PMCID: PMC2504719.
Liu K, Nagase H, Huang CG, Calamita G, Agre P. Purification and functional characterization of aquaporin-8. Biol Cell. 2006 Mar;98(3):153-61. doi: 10.1042/BC20050026. PMID: 15948717.
Nagase H, Yonetani M, Uetani Y, Nakamura H. Effects of child seats on the cardiorespiratory function of newborns. Pediatr Int. 2002 Feb;44(1):60-3. doi: 10.1046/j.1442-200x.2002.01507.x. PMID: 11982873.